Erratum: Corrigendum: Parallel evolution of male germline epigenetic poising and somatic development in animals
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چکیده
منابع مشابه
Epigenetic Remodeling in Male Germline Development
In mammals, germ cells guarantee the inheritance of genetic and epigenetic information across generations and are the origin of a new organism. During embryo development, the blastocyst is formed in the early stage, is comprised of an inner cell mass which is pluripotent, and could give rise to the embryonic stem cells (ESCs). The inner cell mass undergoes demethylation processes and will reest...
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Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus mRNA editing (deamination of adenosine to inosine via the ADAR1 deaminase) coupled to a reverse transcription process to fix RNA sequence modi...
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Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus mRNA editing (deamination of adenosine to inosine via the ADAR1 deaminase) coupled to a reverse transcription process to fix RNA sequence modi...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2016
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1016-1296b